Issue 66 / November - December 2008
It's me, Peter, your intestine!
Peter, maybe now you will snap at me saying, â€śWhat are you trying to do? You are nothing but a set of long pipes, you are the last one to talk about itself!â€ť But take care and do not be so quick to dismiss me; do not make a face at me for the waste material I carry. You need to know first that your organs-the heart, kidneys, liver, and others-cannot work without me. Exaggeration? Not at all! So just listen to me and see for yourself.
Dear Peter, in order for you to understand me better, keep in mind a basic principle about the functioning of living organisms-they all depend on energy use. If no energy enters a living system, then no metabolic activity, no life function can be carried out. Think about a car without fuel. No matter how great the car is, it simply wonâ€™t work without any fuel in the tank. The human body is no different. Plants and animal products which people consume as food provide the body with fuel. However, you cannot make use of the energy in nutrients in the form in which you take them in. They need to undergo a process so that they become usable fuel for us, like crude oil being refined into gasoline to make a car work. This is roughly what my duty is. Without my functioning, you would be devoid of the energy to move a finger, and eventually die. Do you understand now how important a set of pipes I am? You just think that I look like a soft and hollow canal and misjudge me as simple. Well, I know that I donâ€™t have such complex parts as the heart, lungs, and kidneys, but Iâ€™m created as a perfect work of art in plain design.
Although the hoses you use for watering your garden wear out and break in a relatively short time, my walls made of four layers keep functioning through a lifetime without any holes unless I contract a disease like cancer. My outer layer consists of a durable connective tissue, the next one consists of two sets-one horizontally and one vertically laid-of straight muscles, the next layer under that consists of glands spread in a soft connective tissue, and the innermost layer is the epithelial mucosa where the actual absorption takes place.
Now, letâ€™s come to how I achieve digestion, one of your bodyâ€™s vital activities. Actually, there is no place for me to take any pride in it; Iâ€™m just doing as I am ordered. Anyway, the complex processes occurring within my simple-looking walls are just fascinating! Every one of my cells producing the particular enzymes to break up each nutrient is like a separate factory. Some of these enzymes break proteins into different levels of peptides, some break the peptides into amino acids, some break fats into fat acids and glycerin, whereas some break carbohydrates down into glucose. All of these particular enzymes have their sub-branches within themselves. For example the enzymes breaking down fructose (fruit sugar), lactose (milk sugar), and starch are all different. In order for the enzymes to be effective, my inside needs to have the right pH level; the enzymes work in very sensitive conditions. To give you an idea, the enzymes in the stomach-which happens to be the second station the nutrients are destined for before they come to me-work in an acidic environment (pH: 2.5â€“3). In my case however, basic fluids are secreted and this strong acidity is neutralized for my enzymes to work.
My overall length is around 8.5 meters from the first entrance at the stomach to the last exit. The small intestine is nearly 7 meters long and the remaining 1.5-meter section is the large intestine. Although the small intestine is the longest section of the digestive tract, it is still called small since it is smaller in diameter than the large intestine.
The small intestine is also divided into three sections. The very short (25â€“30cm) and relatively thicker part right after the stomach is the duodenum. Bile-which works like detergent and facilitates breaking up fats-produced by the liver and digestive enzymes from the pancreas enter the duodenum. Thus, the nutrients are digested one step further and pass on to the second section (jejunum) and then to the third (ileum). You cannot easily tell apart these final two sections. As blood circulation is more intense in the second section, this section is more reddish and the contractions here are faster and stronger. The third section is narrower and has thinner walls. The blood circulation here is relatively lower and the movements are more limited. The thin membrane of connective tissue (mesentery) around me which attaches me to the abdomen wall and prevents me from knotting up is relatively fatty in this third section.
My most vital parts are the villi-tiny nipples covering the curly surface of my inner wall like a carpet. Shaped like the fingers of a glove, villi yield an enormously large inner surface. They contain a net of capillaries and lymph canals. In addition to the glands secreting the enzymes to break down nutrients, the secretion of certain glands protects me against the destructive effect of the stomach acid. Some cells secrete mucus for lubrication and protection of the passing nutrients. As some cells of the villi secrete digestive enzymes, some of my cells absorb the nutrients broken down until the final phase and pass them to the bloodstream.
Peter, how can some guys mistake such a splendid mechanism as a work of unconscious nature? What Iâ€™m telling you about is a manifestation of such great knowledge and might that it leaves you spellbound. I know the characteristics of foods, I know about the other organsâ€™ needs, I adjust various enzymes and an absorption system, I fit them in a limited spaceâ€¦ In addition, I do all these in the most ideal way, without any waste or flaw! Câ€™mon Peter, can all these happen by themselves? Now, if I were to start telling everyone about the absorption mechanism in detail, they would probably see those cells as divine beings! The One who assigned special carrier molecules and a system for every nutrient molecule, has placed two transfer systems as blood and lymph pathways in every single one of those millions of villi! The blood pathway passes amino acids, water and salts into the blood directly, whereas the lymphatic pathway absorbs fats to pass them to the blood indirectly. After absorption, the nutrients become a property of the body and they are carried in the bloodstream to all the cells waiting for them in need.
Well, what about the waste then? Since everything you eat is not beneficial and usable, and some things are even toxic, they should be disposed of as soon as possible. The unabsorbed remnants are still too watery to be disposed of; sending them away as they are will be a waste of water and minerals. But donâ€™t worry, everything is perfectly planned! Now the large intestine comes on duty. In this 1.5-meter section, the water of the waste and certain minerals are absorbed, and the waste solidifies. The large intestine is also divided into three sub-sections. The pouch connected to the junction of the small and large intestines is named the cecum and thereâ€™s the appendix at its end. This end sometimes festers and you have to have it removed in an appendectomy. Now, thereâ€™s this made-up story that the appendix was once longer since your ancestors only ate plants, that it has evolved into a shorter form for I now eat more meat, so on and so forthâ€¦ Bah! Nothing is created in vain, Peter. If it didnâ€™t have a duty, it simply wouldnâ€™t be created. Only after some time did it dawn on them, after researchers proved that it is so necessary, that as a lymphoid organ, rich in blood vessels, it produces antibodies to fight the germs which somehow make their way into me.
The rest of the large intestine is the colon and the rectum. The mucosa covering my inner surface is rather smooth. It secretes mucus to facilitate the removal of waste. In addition, useful bacteria are made to work in abundance in the large intestine for your needs. These bacteria synthesize the group B vitamins like B12, thiamin, and riboflavin, along with vitamin K. You see how all the processes are carried out so splendidly? If it werenâ€™t for vitamin K, your blood would fail to coagulate, and the slightest injury to your blood vessels would kill you. Could you ever have imagined that what looks to you like a sewage canal could produce vitamins of vital significance? Your Creator has infinite wisdom.
Peter, now you may wonder how the acts of this organ which resembles a long hose are regulated, how the nutrients inside are propelled, and then thrown out. To put it briefly, the â€świllfulâ€ť part of your brain does not even know about it. Indeed, if it knew, it would be constantly busy with me and unable to do anything else.
Under the control of the autonomous nervous system, the straight muscles of my walls gradually contract in waves-this is squeezing act is called peristalsis. The nerve fibers connected to me fall into two basic categories-sympathetic and parasympathetic. As the sympathetic fibers pressure me to slow down, parasympathetic fibers stimulate me to act. Thus, I try to keep a balanced functioning between these two opposite effects. When the waste material I propel this way assumes a state to be disposed of, it reaches the rectum, and when the walls here strain, I make a natural call to you that I need to get rid of garbage. This is the step where your will has a partial interference.
Colon cancer, which troubles many people today, appears in this final section. The major reason is consuming too much meat and fatty foods, lack of movement, and leading a stressful life. When these are combined, I fail to function properly. If you want to help me at that, you should consume fiber-rich foods such as fruit and vegetables, and also lead a peaceful life. My web of nerves is amazingly rich and complex. Therefore, I am sensitive to nervous changes. If you feel down or sad, and if you suffer too much stress, I begin to go into spasms. Then I fail to dispose of waste, the toxic material inside me begins to damage my inner walls and eventually increases your cancer risk. Therefore, youâ€™d better take up the habit of a glass of warm water when you get up in the morning, and try to have regular meals at the same times of the day. Most importantly, always have fresh green vegetables on your table, reduce meat intakeâ€¦ and it would be great if you could afford to consume olive oil rather than any other.
Hey, wait! I was about to forget the most important point. If you donâ€™t have any peace of mind, all of these will be useless. This doesnâ€™t mean that you will never worry; after all, this world is a testing ground and you are a human being like anyone else. However, if you give in to troubles and get overcome by feelings like panic, fatigue, and hopelessness, then my functioning will be upset. So, troubles faced with active patience and effort without giving up hope do not harm me much.
Peter, I do not wish you to wait until you see colon cancer patients disposing of waste through a hole in their belly into a plastic bag before you feel grateful for the blessings you enjoy. Actually, maybe I have told you at most a tenth of what I know about myself. Anyway, I think even this much will give you an idea of what a work of art I am. Thanks for listening to me, Peter!
Irfan Yilmaz is a professor of biology at Dokuz EylĂĽl University, Izmir, Turkey.